Deployments of wMel-infected Aedes aegypti mosquitoes resulted in an 83% reduction in the application of perifocal insecticide spraying, consistent with lower dengue case notifications in wMel-treated areas. These results show that the Wolbachia intervention effect demonstrated previously in a cluster randomised trial was also measurable from routine surveillance data.
John Henryism and Superwoman Schema are statistically distinct constructs. Understanding culturally-specific coping may inform how racism gets under the skin. The findings have implications for understanding intersectional stress-coping dynamics.
We propose the log-contrast estimator that can eliminate bias caused by differential healthcare-seeking behavior in cluster-randomized test-negative designs and demonstrate how to improve precision by adjusting for covariates.
Introgression of wMel into A. aegypti populations was effective in reducing the incidence of symptomatic dengue and resulted in fewer hospitalizations for dengue among the participants.
US suicide and overdose mortality rates are rising for working-age adults with no college education. Manufacturing has been declining in the US for decades, as precarious work has been increasing. Economic contraction and job loss have been linked to suicide, depression and substance abuse. This study examined individual-level data from a large established cohort study of autoworkers in Michigan followed from 1970 to 2015, covering the recent period of decline in the US automobile industry. We found that suicide was associated with employment status; the hazard rate was 16 times higher among inactive workers who had terminated employment. When compared to rate among retirees, the rate of suicide combined with overdose was elevated for workers who left work younger, when leaving was less likely to be voluntary.
We demonstrate a significant reduction in dengue incidence following successful introgression of Wolbachia into local Ae. aegypti populations in an endemic setting in Indonesia. These findings are consistent with previous field trials in northern Australia, and support the effectiveness of this novel approach for dengue control.
Women who experience HDPs have 41% lower risk for developing nonbreast cancer and have lower later-life blood pressures if they inherit a T allele of the common functional IGF1R variant rs2016347. These novel findings add to a growing body of epidemiologic evidence pointing to a clinically significant exposure interaction between HDPs and rs2016347 (effect modification) and strongly implicate a mechanistic role for the IGF1 axis in driving both cardiovascular and cancer risk, particularly in women with a history of HDPs. Because nonbreast cancers afflict 30% of women in their lifetime, confirmation of this study's findings could lead to improved individualized cancer screening, as well as novel prevention strategies.